Background: Atopic dermatitis (AD) is a common, chronic, relapsing, itchy, skin condition occurring in patients with a personal or family history of atopy, and there is clinical association among different allergic disease in a way that treating one of them will improve the other. Many studies worldwide showed presence of AD in asthmatic children with different prevalence among countries and showed clinical improvement in asthma control on treatment of atopic dermatitis. Therefore, this study was conducted to assess the prevalence of atopic dermatitis among Libyan asthmatic children. Methods: This is an observational cohort study on asthmatic Libyan children who were treated and followed up at Tripoli children hospital in Tripoli, Libya. It carried out on 300 children suffering from asthma admitted from pediatric outpatient department as well as from emergency department and asthma clinic over a period of 24 months; from December 2017 to December 2019. The parents were asked to complete a questionnaire to collect the needed information after their consent being taken. To assure the accuracy and consistency of the methodology (sampling procedure, measurements, and a collection of the data), a standardized protocol was prepared. Data were entered in SPSS statistical package and consequently were analyzed and presented as descriptive statistics. Results: The prevalence of atopic dermatitis among asthmatic Libyan children was 16.7% in our study. The results showed significant relationship between address and prevalence of atopic dermatitis. Conclusion. Further studies are required to address the ethnicity, environmental factors, skin type and others attributed to this problem and we recommend all pediatricians to look for AD in asthmatic children and treat it accordingly arabic 7 English 56
Hisham Alrabty, Munera Addala(5-2020)

Exposure to chemicals has been shown to adversely affect CNS health in rodents and humans. The objective was to evaluate, in-vivo, the effects of trichloroethane (TCE), a ubiquitous environmental contaminant, on the integrity of neural cells. A group of albino mice was injected intraperitoneally twice weekly for three weeks with TCE (100 and 400 µg/kg). Animals were followed up for signs of toxicity and death. Alterations in neural tissues have also been investigated by histopathology The results showed a large number of degenerative neural cells (pyknosis of nuclei, DNA fragmentation, chromatin condensation) in the 100 and 400 µg/kg TCE-treated groups comparing to controls. Although there were no significant effect on the neural cell counts, the pattern of increased degenerative cells in TCE-treated groups was higher compared to controls. The results also showed that TCE led to a significant increase in the percent of degenerative neurons. There was also a significant reduction in the percent of neurons. These results correlated with the increase in the percent of glia. This study indicates that TCE exposure had detrimental impact on neural cells, and that neurons are more vulnerable to TCE than glia in this in-vivo mouse model.
Mohamed A. Al-Griw, Naser M. Salama, Soad A. Treesh, Lubna N. Algadi, Abdul hakim Elnfati(7-2015)

Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The aim of this study was to characterize the molecular support of carbapenem-resistant A. baumannii clinical isolates recovered from four hospitals in Tripoli, Libya. Bacterial isolates were identified and antibiotic susceptibility testing was per-formed using automated system. Carbapenem resistance determinants were studied phenotypically using two dif-ferent techniques: E-test; chromogenic culture media. Polymerase chain reaction (PCR) amplification was used to determine the presence of bla OXA23 and blaOXA51 genes among isolates. A total of 119 isolates were characterized, overall the resistance prevalence was extremely high for aminoglycosides (79-96.6%), fluoroquinolones (94-96%), cephalosporins (96.6-100%) and carbapenemes (93.2-100%), all isolates were susceptible to colistin. In addition, 97.5% of isolates were identified as multidrug resistance (MDR). Varying degree of phenotypic detection of car-bapenemes was determined; highest levels of carbapenemes were detected using chromogenic media (76.5%) com-pared with E-test (45.4 %). The carbapenem resistance-encoding genes detected were blaOXA23 (84%) and blaOXA51 (73.1%); the highest occurrence of blaOXA23 was demonstrated in Tripoli’s Central Hospital (5/5; 100%) then in Tripoli Medical Center (44/51; 86.27%). The co-occurrence of these genes was demonstrated in (75/119; 63%) showing dissemination of carbapenemes resistance MDR A. baumannii in hospitals. This study shows that the high prevalence of OXA-23 contribute to antibiotic resistance in … arabic 14 English 113
Nada Elgrew, Abdulla Bashein(1-2016)