Fungi are a huge source of unexplored bioactive compounds. Owing to their biological activities, several fungi have shown commercial application in the health industry. Tuber aestivum Vittad. is one such edible fungi with an immense scope for practical biological applications. In the present study, the anti-angiogenic activity of petroleum ether and ethanol extracts of T. aestivum was investigated using the chick chorioallantoic membrane assay and compared to the positive controls silibinin and lenalidomide. Both the extracts showed a dose-dependent anti-angiogenic response. The extracts were also assessed for their anti-inflammatory potential by lipoxygenase-inhibition assay. The IC50 values for LOX inhibition assay, computed by the Boltzmann plot, were 368.5, 147.3 and 40.2 μg/mL, for the petroleum ether extract, ethanol extract, and the positive control ascorbic acid, respectively. The ethanol extract of T. aestivum showed superior anti-angiogenic and anti-inflammatory activity than the petroleum ether extract. Compositional investigation of the extracts by GC–MS revealed the presence of various bioactive compounds. The compounds were correlated to their anti-angiogenic and antiinflammatory activity based on a meticulous literature search. arabic 25 English 145
Sandesh J. Marathe, Abdulla Bashein, (1-2020)

GLUT4 translocation in response to insulin involves the PI3K/Akt pathway and IR mediated phosphorylation of CAP (SORBS1), and formation of the CAP:Cbl. These pathways act in a coordinated manner to regulate glucose, lipid and protein metabolism. In previous studies, T228A polymorphism of SORBS1 gene has been shown to be a protective factor for obesity, type-2 diabetes mellitus (T2DM), polycystic ovary (PCOs), and lacunars infarction. Objectives: The objective of this study was to investigate the association between this polymorphism and T2DM, gestational diabetes (GDM), and obesity. Methods: Genotyping was achieved by PCR-RELP in 227 individuals chosen randomly from the out patient’s clinics of Al-Jala maternity hospital of Tripoli and Gharian hospital, including: 63 T2DM patients, 59 GDM patients, 57 obese, 47 healthy control individuals from Libyan pregnant women population (North-West Region). Results: The results revealed that this polymorphism has no association with T2DM, GDM, and obesity in comparison with the control sample. Conclusion: T228A polymorphism of SORBS1 gene is not associated with the pathological conditions studied. arabic 15 English 98
Abdulla Bashein(1-2013)

Lipid biochemistry can seem overwhelming, which is why it needs to be explained in a simple and straightforward manner. Ashour Saleh Eljamil, a renowned professor of biochemistry, has written this textbook for undergraduate students in the medical sciences, but its a resource that anyone can use to bolster their knowledge about this important subject. To fully understand biochemistry, you need to know how biomolecules are structured, which is why the first chapter emphasizes the individual chemical structure of various lipid classes. Youll also learn how dietary lipids are digested and absorbed as well as how their metabolism works in separate chapters focusing on fatty acids synthesis, fatty acid oxidation, acylglycerols and sphingolipids, glycolipids, cholesterol, plasma lipoproteins, steroid hormones, and fat-soluble vitamins. While scientists have studied lipid biochemistry for three centuries, its only in the past few decades that weve begun to understand why its so important. Gain a clearer understanding of the world with insights about bile acids, sterols, carotenoids, sex hormones, vitamin K and much, much more when you dive into the world of Lipid Biochemistry. arabic 5 English 35
Ashour Eljamil(3-2015)